‘Design Science Methodology’ (DSM) focuses on design-science research approaches and science-based design approaches, both aiming to link science and design. A design-science research project aims to develop design knowledge; a science-based design project aims to design an artefact, thereby applying scientific design knowledge. Design science methodology offers also a systematic approach to link knowledge and skills obtained in other courses to practice. Science develops knowledge about what already is, whereas design involves human beings using knowledge to create what should be, things that do not yet exist. Design, as the activity of changing existing situations into desired ones, therefore appears to be the core competence of all professional activities. DSM in this course is applied to research problems in the domain of Architecture, Engineering, Construction and Operation (AECO). For the management of AECO projects, Systems Engineering principles are applicable. Systems Engineering is a well-known method also from practice for structuring complex (design) projects. Structuring the design data and the design process allows for better project management and better quality maintenance. Building Information Modelling is a technique for generating and leveraging building data to design, construct and operate the building during its lifecycle. BIM allows all stakeholders to have access to the same information at the same time through interoperability between technology platforms. With a proper knowledge, BIM techniques can support Systems Engineering methods.